These sources provide background on individual probiotics, fibers, botanicals, digestive outcomes, or skin-related mechanisms. A study on one ingredient does not establish the effect of the complete Neotonics formula.
Priority is given to peer-reviewed research and indexed scientific databases. Study population, strain, dose, preparation, route of use, and measured outcome all affect relevance.
Evidence categories used in this library
Ingredient evidence
Research on a named probiotic, fiber, botanical, or preparation. Relevance depends on strain, dose, route, population, and outcome.
General gut and microbiome evidence
Research about mechanisms or relationships that provides background context but does not test the Neotonics formula.
Finished-product evidence
No controlled finished-product clinical trial is cited in the current library. Ingredient or mechanism studies must not be presented as proof that Neotonics produces the same result.
The controlling factual record for amounts and label disclosures is the Neotonics Ingredients & Supplement Facts formula record.
Evidence hierarchy
Prebiotic fiber and inulin
- Visuthranukul C, et al. Inulin supplementation and metabolic outcomes. Scientific Reports. 2022.
- Thompson SV, et al. Soluble fiber supplementation: systematic review and meta-analysis. American Journal of Clinical Nutrition. 2017.
Dandelion, ginger, and fenugreek context
- Clare BA, et al. Human study of Taraxacum officinale leaf extract. 2009.
- Warashina T, et al. Dandelion-root constituents and human skin fibroblasts. 2012.
- Wang X, et al. Short-term ginger juice intake and gut microbiota. Frontiers in Microbiology. 2021.
- Bruce-Keller AJ, et al. Fenugreek and gut microbiota in an animal model. Scientific Reports. 2020.
Bacillus coagulans and digestive research
- Nyangale EP, et al. Prebiotics and B. coagulans effects on fecal microbiota. Anaerobe. 2014.
- Rogha M, et al. Randomized placebo-controlled synbiotic trial in IBS. 2014.
- Dolin BJ. Proprietary B. coagulans preparation in diarrhea-predominant IBS. 2009.
- Majeed M, et al. Double-blind randomized pilot study of B. coagulans MTCC 5856. Nutrition Journal. 2016.
- Minamida K, et al. Dietary fiber with B. coagulans and bowel outcomes. 2015.
Phase 1 ingredient evidence sources
Bacillus coagulans
- NIH Office of Dietary Supplements. Probiotics: Health Professional Fact Sheet.
- Outcome-specific probiotic efficacy in IBS: systematic review and network meta-analysis.
Inulin
- Inulin and human gut microbial composition: systematic review.
- Chicory inulin, bifidobacteria and bowel function: systematic review and meta-analyses.
Babchi
- NCBI LiverTox: psoralen and Psoralea corylifolia safety reports.
- Botanical safety in vitiligo and hypermelanosis: systematic review.
Ginger
- NCCIH. Ginger: Usefulness and Safety.
- Ginger on human health: systematic review of randomized trials.
Slippery elm
Gut–skin axis and probiotic context
- Gut–Skin Axis: Current Knowledge of Microbial Dysbiosis and Skin Conditions.
- Impact of the Gut Microbiome on Skin Health.
- The Gut Microbiome as a Major Regulator of the Gut–Skin Axis.
- The Role of Probiotics in Skin Health and Related Gut–Skin Research.
Different probiotic strains are not interchangeable. Results from a clinical population or a specific dose should not be converted into a guaranteed outcome for another strain, dose, population, or finished supplement.
Read the formula and label guide →